Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues

نویسندگان

  • B Wulkersdorfer
  • T Wanek
  • M Bauer
  • M Zeitlinger
  • M Müller
  • O Langer
چکیده

Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug-drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)-a noninvasive imaging method--plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs.

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عنوان ژورنال:

دوره 96  شماره 

صفحات  -

تاریخ انتشار 2014